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Sarah Kim-Hellmuth
Helmholtz Munich
Institut für Translationale Genomik
Ingolstädter Landstraße 1
85764 Neuherberg
Klinikum der Ludwig-Maximilians-Universität München
Kinderklinik und Kinderpoliklinik im Dr. von Haunersches Kinderspital
Lindwurmstr. 4
80337 München
Research areas
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Human Genetics
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Functional Genomics
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Immunology and Immunogenomics
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Personalised Medicine
- Projects
- Research Groups
Resume
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since 2022
Emmy Noether Research Group Leader with joint appointment at the Dr. von Hauner Children’s Hospital, University Hospital LMU Munich and the Institute of Translational Genomics, Helmholtz Munich – German Research Center for Environmental Health, Neuherberg -
since 2021
Specialist in Human Genetics at the Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital LMU Munich -
2021
Helmholtz Young Investigator Group Leader -
since 2020
Principal Investigator of Ped-COVID-19 study at the Dr. von Hauner Children’s Hospital, University Hospital LMU Munich and Munich Child Health Alliance -
2019–2021
Resident at the Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital LMU Munich -
2015–2019
Postdoctoral scientist at the New York Genome Center and Columbia University,
Lead analyst of Genotype-Tissue Expression (GTEx) consortium and subgroup leader of the cell type composition analysis team -
2014
MD Doctorate (Summa cum laude), Division of Clinical Pharmacology, Department of Internal Medicine, Ludwig-Maximilians-University, Munich -
2011–2015
Resident at the Institute of Human Genetics, University Hospital, University of Bonn -
2011–2015
Research fellow at the Institute of Human Genetics and Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn
Guest researcher at Statistical Genetics, Max-Planck-Institute of Psychiatry, Munich -
2009–2011
MD thesis research fellow at the Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn -
2002–2009
Medical training at Ludwig-Maximilians-University and Technical University of Munich
Selection of
publications
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Flynn, E., Tsu, A., Kasela, S., Kim-Hellmuth, S., Aguet, F., Ardlie, K. G., Bussemaker, H. J., Mohammadi, P. & Lappalainen, T.
Transcription factor regulation of eQTL activity across individuals and tissues.
Plos Genet 18, e1009719 (2022).
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Brandt, M. K., Kim-Hellmuth, S., Ziosi, M., Gokden, A., Wolman, A., Lam, N., Recinos, Y., Hornung, V. K., Schumacher, J. & Lappalainen, T.
An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?
PLoS Genet 17(7), (2021).
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Petersheim, D., Behrends, U., Kim-Hellmuth, S., [...]
Swarm Learning for decentralized and confidential clinical machine learning.
Nature 1–7 (2021).
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de Goede, O. M., Nachun, D. C., Ferraro, N. M., Gloudemans, M. J., Rao, A. S., Smail, C., Eulalio, T. Y., Aguet, F., Ng, B., Xu, J., Barbeira, A. N., Castel, S. E., Kim-Hellmuth, S., [...]
Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.
Cell (2021).
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Barbeira, A. N., Bonazzola, R., Gamazon, E. R., Liang, Y., Park, Y.*, Kim-Hellmuth, S., [...]
Exploiting the GTEx resources to decipher the mechanisms at GWAS loci.
Genome Biol. 22, 49–24 (2021).
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GTEx Consortium. Lead analyst: Kim-Hellmuth, S.
The GTEx Consortium atlas of genetic regulatory effects across human tissues.
Science 369, 1318-1330 (2020).
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Kim-Hellmuth, S. et al.
Cell type specific genetic regulation of gene expression across human tissues.
Science 369 (2020).
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Oliva, M., Muñoz-Aguirre, M., Kim-Hellmuth, S., [...]
The impact of sex on gene expression and its genetic regulation across human tissues.
Science 369 (2020).
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Demanelis, K., Jasmine, F., Chen, L. S., Chernoff, M., Tong, L., Delgado, D., Zhang, C., Shinkle, J., Sabarinathan, M., Lin, H., Ramirez, E., Oliva, M., Kim-Hellmuth, S., [...]
Determinants of telomere length across human tissues.
Science 369 (2020).
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Kim-Hellmuth, S. et al.
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Nat Commun 8, 266 (2017).
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Kim-Hellmuth, S. & Lappalainen, T.
Concerted Genetic Function in Blood Traits.
Cell 167, 1167–1169 (2016).
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Kim, S. et al.
Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.
Nat Commun 5, 5236 (2014).
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Kim, S. et al.
Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
Eur. J. Immunol. 44, 807–818 (2014).
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Kim, S. et al.
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Eur. J. Immunol. 40, 1545–1551 (2010).
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Hornung, V., Ellegast, J., Kim, S., [...]
5'-Triphosphate RNA is the ligand for RIG-I.
Science 314, 994–997 (2006).
Activities
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Salon Sophie Charlotte 2023
Aufklärung 2.0
In 2023, the Berlin-Brandenburg Academy of Sciences and Humanities will once again open its doors to the public and invite visitors to the Salon Sophie Charlotte - this year under the motto "Enlightenment 2.0. The ten members of Die Junge Akademie who joined in the summer of 2022 will participate in the Salon with their own activity.
Topics:
- Starts on
- 13.05.23
Event access: Public
Berlin-Bradenburgische Akademie der Wissenschaften, Markgrafenstraße 38, 10117 Berlin
Link18:00
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